Andrew Cavigli

Title: Andrew Cavigli and In-Process Verification of pH Probe Calibration

Introduction

Andrew Cavigli is an inventor associated with Amgen Inc. in Boston, Massachusetts. His patent work addresses verification of pH probe calibration during a low-pH viral inactivation process.

Latest Patents

Cavigli is credited with 1 patent, titled “In-process verification of calibration status of pH probes.” The invention describes an automated process that adds an elution pool and acid to a first vessel. Once pH probes confirm that the pool has reached a sufficiently low pH, the pool moves to a second vessel for another pH check and a holding period intended to reduce viral concentration. The pool is then neutralized, filtered, and transferred to a third vessel.

While the pool is processed, the first vessel receives a buffer with a known pH. Its measured pH is compared with the readings from the vessel’s probes to determine whether recalibration is needed. After the pool leaves the second vessel, that vessel is also checked using a known-pH buffer. The cycle can then repeat with a new elution pool.

Career Highlights

Cavigli’s listed patent focuses on process monitoring and equipment verification in biopharmaceutical manufacturing. By checking probe readings against known-pH buffers during production, the method provides a way to assess calibration status as the process proceeds.

Collaborations

Cavigli’s listed coworkers include Venkatesh Natarajan and Marco DeLiso. The patent’s subject matter reflects work relevant to automated process control and viral inactivation.

Conclusion

Andrew Cavigli’s patent describes an in-process approach to checking pH probe calibration alongside low-pH viral inactivation, connecting measurement verification with biopharmaceutical manufacturing operations.