Location History:
- Strasbourg, FR (1994)
- 67085 Strasbourg, FR (1995)
Company Filing History:
2 out of 870 
1 out of 832,891 Years Active: 1994-1995
Title: Andree Krust: Innovator in Molecular Biology
Introduction
Andree Krust is a notable inventor based in Strasbourg, France. He has made significant contributions to the field of molecular biology, particularly in the study of hormone receptors and their implications in diseases such as hepatocellular carcinoma.
Latest Patents
Krust holds 3 patents, with his latest focusing on a steroid/thyroid hormone receptor-related gene. This research involves a previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC). The study utilized this integration as a probe to clone complementary DNA from a human liver cDNA library. Nucleotide sequence analysis revealed that the cellular gene, named hap, shares structural similarities with DNA-binding hormone receptors. Notably, six out of seven hepatoma and hepatoma-derived cell lines express a 2.5 kb hap mRNA species, which is undetectable in normal adult and fetal livers but present in all non-hepatic tissues analyzed. Low stringency hybridization experiments indicated the existence of hap-related genes in the human genome. The cloned DNA sequence is instrumental in preparing pure hap protein and serves as a probe for detecting and isolating complementary DNA and RNA sequences. The hap protein is identified as a retinoic acid (RA) receptor known as RAR-.beta., which is transcriptionally up-regulated by retinoic acid, suggesting its promoter region may contain a retinoic acid responsive element (RARE).
Career Highlights
Throughout his career, Andree Krust has worked with prestigious institutions, including the Institut Pasteur. His research has significantly advanced the understanding of hormone receptors and their roles in various biological processes.
Collaborations
Krust has collaborated with notable colleagues, including Agnes Marchio and Pierre Tiollais, contributing to the advancement of molecular biology research.
Conclusion
Andree Krust's innovative work in the field of molecular biology has led to important discoveries regarding hormone receptors and their implications in health and disease. His contributions continue to influence research and understanding in this vital area of science.