Company Filing History:
Years Active: 2022-2025
Title: Innovations of Andreas Busch in Glycosylated Lysosomal Proteins
Introduction
Andreas Busch is an accomplished inventor based in Ebringen, Germany. He has made significant contributions to the field of biochemistry, particularly in the development of glycosylated lysosomal proteins. With a total of two patents to his name, his work focuses on improving therapeutic efficacy for various diseases.
Latest Patents
Busch's latest patents revolve around a lysosomal protein composition that includes a variety of lysosomal proteins, which are diversely glycosylated according to a specific glycosylation pattern. This pattern features at least 45% paucimannosidic N-glycans. The invention also details a method for producing this lysosomal protein composition in bryophyte plants or cells. Notably, the lysosomal proteins can include α-Galactosidase for treating Fabry Disease and β-Glucoceramidase for Gaucher's Disease. The unique glycosylation achieved through this method results in improved therapeutic efficacy, surprisingly even without the common mannose-6-phosphate found in CHO cell-produced lysosomal proteins.
Career Highlights
Andreas Busch is currently associated with Eleva GmbH, where he continues to innovate in the field of biochemistry. His work has garnered attention for its potential to enhance treatment options for lysosomal storage disorders.
Collaborations
Busch collaborates with notable colleagues, including Paulina Dabrowska-Schlepp and Fode Benjamin, who contribute to the research and development efforts at Eleva GmbH.
Conclusion
Andreas Busch's innovative work in glycosylated lysosomal proteins represents a significant advancement in therapeutic applications for lysosomal storage diseases. His contributions are paving the way for improved treatment methodologies in the medical field.