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Title: Andrea Mattevi: Innovator in Biocatalysis and Therapeutic Agents
Introduction
Andrea Mattevi is a prominent inventor based in Pavia, Italy. She has made significant contributions to the fields of biocatalysis and therapeutic agents, holding a total of 2 patents. Her work focuses on innovative processes that have the potential to impact various industries, including pharmaceuticals and biotechnology.
Latest Patents
One of her latest patents is titled "Regioselective hydroxylation of isophorone." This invention relates to a novel process for producing ketoisophorone through the biocatalytic conversion of isophorone. The process involves a one-pot biocatalytic system for converting α-isophorone in a two-step oxidation process. The first oxidation is catalyzed by a heme-containing oxidoreductase, such as a cytochrome P450 monooxygenase, followed by another oxidation that can be either a chemical or biocatalytic reaction. This invention also provides polypeptides and nucleic acid sequences coding for cytochrome P450 monooxygenase with modified substrate selectivity and reactivity compared to the wild-type enzyme. Ketoisophorone is recognized as a valuable building block in the synthesis of vitamins and carotenoids.
Another significant patent by Mattevi is related to "Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2." These derivatives are useful as therapeutic agents for preventing and treating diseases associated with the activity of histone demethylases, such as tumors and viral infections. The invention includes the preparation of these compounds, compositions containing them, and their therapeutic applications.
Career Highlights
Throughout her career, Andrea Mattevi has worked with notable organizations, including DSM IP Assets B.V. and Università Degli Studi Di Roma "La Sapienza." Her expertise in biocatalysis and medicinal chemistry has positioned her as a key figure in her field.
Collaborations
Some of her notable collaborators include Werner Bonrath and Martin Schürmann. Their joint efforts have contributed to advancing research and development in the areas of her patents.
Conclusion
Andrea Mattevi's innovative work in biocatalysis and therapeutic agents showcases her significant contributions to science and technology. Her patents reflect her commitment to developing processes that can lead to