Ana Maria Tari is a distinguished inventor based in Houston, TX, who has made significant contributions to cancer treatment. With a total of 11 patents to her name, her work centers around innovative approaches to combat chronic myelogenous leukemia (CML).

Latest Patents

One of Ana Maria Tari's notable patents is focused on the "Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to Grb2 or Crk1." This invention presents novel compositions and methods for treating cancer, specifically targeting CML. The compositions comprise antisense oligonucleotides designed to hybridize to Grb2 and Crkl nucleic acids, which interact with the tumorigenic protein bcr-abl. By using these compositions either alone or in combination with other antisense oligonucleotides directed to bcr-abl, the proliferation of CML cancer cells is effectively inhibited.

Another significant innovation by Tari involves the development of an improved delivery system for antisense oligonucleotides. This system utilizes a liposomal composition that consists essentially of neutral phospholipids encapsulating the antisense oligonucleotide, selected from phosphodiester oligonucleotides, phosphorothioate oligonucleotides, and p-ethoxy oligonucleotides.

Career Highlights

Ana Maria Tari is affiliated with the University of Texas System, where she continues her groundbreaking research in cancer therapies. Her expertise in the field of molecular medicine underscores her commitment to advancing the treatment landscape for patients suffering from leukemia.

Collaborations

Throughout her career, Tari has collaborated with esteemed colleagues, including Gabriel Lopez-Berestein and Ralph B. Arlinghaus. These partnerships have played a crucial role in enhancing her research and amplifying the impact of her inventions in the field of cancer treatment.

Conclusion

Ana Maria Tari's innovation and dedication to cancer research have positioned her as a key figure in the fight against chronic myelogenous leukemia. Her patents not only contribute to the scientific community but also offer hope for effective treatments for patients affected by this formidable disease. With her continued work at the University of Texas System, Tari is poised to make further advancements in the realm of medical science.

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