La Jolla, CA, United States of America

Amy L Blount


Average Co-Inventor Count = 5.0

ph-index = 1

Forward Citations = 1(Granted Patents)


Company Filing History:


Years Active: 2004-2008

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2 patents (USPTO):Explore Patents

Title: Innovations of Amy L Blount

Introduction

Amy L Blount is a notable inventor based in La Jolla, California. She has made significant contributions to the field of biochemistry, particularly in the study of protein hormones. With a total of two patents to her name, her work has implications for understanding regulatory pathways in various biological systems.

Latest Patents

Her latest patents include a method of inhibiting the formation of inhibin/betaglycan complexes with an anti-betaglycan antibody. Inhibins and activins are protein hormones that reciprocally modulate a diversity of regulatory pathways. Competitive binding experiments revealed that betaglycan, the type III TGF-β receptor, also functions as an inhibin receptor. Betaglycan augments the binding of inhibin to the ActRII activin receptor. By augmenting inhibin binding to ActRII, betaglycan effectively sequesters ActRII away from activin and thereby reduces activin signaling. In addition, the ActRII-betaglycan complex may generate novel signals distinct from those initiated by activin signaling via ActRII and ALK4. Betaglycan is produced in discrete nuclei of the rat brain and by specific cell types within the adult rat pituitary, testis, and ovary. The presence of betaglycan within inhibin-responsive tissues and cell types, together with the ability of this proteoglycan to bind inhibin and to confer inhibin sensitivity, is consistent with a role of betaglycan as an inhibin-specific receptor mediating inhibin responses within various tissues.

Career Highlights

Amy L Blount has established herself as a key figure in her field through her innovative research and patent contributions. Her work has advanced the understanding of hormonal interactions and their effects on biological processes.

Collaborations

She has collaborated with notable colleagues such as Wylie Walker Vale, Jr. and Kathy A Lewis, further enhancing the impact of her research.

Conclusion

Amy L Blount's contributions to the field of biochemistry through her patents and research collaborations highlight her role as an influential inventor. Her work continues to pave the way for advancements in understanding protein hormone interactions.

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