Location History:
- New York, NY (US) (2022)
- Princeton, NJ (US) (2023)
Company Filing History:
Years Active: 2022-2023
Title: Innovations of Amit Singer in Electron Microscopy
Introduction
Amit Singer is a prominent inventor based in New York, NY (US). He has made significant contributions to the field of electron microscopy, holding 2 patents that showcase his innovative approaches to particle reconstruction and imaging techniques.
Latest Patents
One of his latest patents is titled "Fully automatic, template-free particle picking for electron microscopy." This invention describes systems and methods for the fully automatic locating and extracting of a plurality of two-dimensional projections of particles in a micrograph image. The process involves assembling a set of reference images from a micrograph image by analyzing image data in partially overlapping windows. A normalized cross-correlation is calculated to identify locations in the micrograph that contain two-dimensional projections of different instances of the particle. This method ultimately aids in determining the three-dimensional structure of the particle.
Another notable patent is "Anisotropic twicing for single particle reconstruction using autocorrelation analysis." This invention outlines methods for digitally reconstructing an unknown 3D structure of a target molecule using orthogonal extension. It involves capturing a plurality of 2D images of the target molecule and calculating an estimated low-order moment of the unknown 3D structure. By identifying a homologous molecule with a known 3D structure, the invention calculates estimated expansion coefficients for the unknown structure, leading to a generated 3D reconstruction of the target molecule.
Career Highlights
Amit Singer is affiliated with Princeton University, where he continues to advance research in electron microscopy and molecular imaging. His work has garnered attention for its innovative methodologies and practical applications in scientific research.
Collaborations
Some of his notable coworkers include Ayelet Heimowitz and Joakim Anden, who contribute to the collaborative efforts in his research projects.
Conclusion
Amit Singer's contributions to the field of electron microscopy through his patents reflect his commitment to advancing scientific knowledge and technology. His innovative approaches are paving the way for future developments in molecular imaging and particle reconstruction.