Company Filing History:
Years Active: 2008
Title: Innovations of Altaf Mohammad in Histone Acetyltransferase Inhibition
Introduction
Altaf Mohammad is an accomplished inventor based in Jammu and Kashmir, India. He has made significant contributions to the field of biochemistry, particularly in the development of inhibitors for histone acetyltransferases. His work has the potential to impact cancer research and treatment.
Latest Patents
Altaf Mohammad holds a patent titled "Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof." This patent describes the purification of prenylated benzophenones from fruit rinds and evaluates their effectiveness as inhibitors for histone acetyltransferases p300 and PCAF. The findings indicate that these compounds are potent HAT inhibitors, with IC values of 1 µM for p300 and 15 µM for pCAF. The inhibitors significantly repress p300 HAT-dependent transcriptional activation from in vitro assembled chromatin templates, while showing no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs, making them useful as biological switching molecules for evaluating the roles of p300 and PCAF in cellular functions. Furthermore, they may serve as new chemical entities for the development of anticancer drugs.
Career Highlights
Altaf Mohammad is affiliated with the Jawaharlal Nehru Centre for Advanced Scientific Research, where he conducts his research. His work has garnered attention for its innovative approach to understanding the mechanisms of histone acetylation and its implications in cancer biology.
Collaborations
Altaf has collaborated with notable colleagues, including Kundu Tapas Kumar and Karanam Balasubramanyam, to advance research in this critical area of study.
Conclusion
Altaf Mohammad's innovative work in the field of histone acetyltransferase inhibition showcases the potential for new therapeutic strategies in cancer treatment. His contributions are paving the way for future research and development in this vital area of biochemistry.