Location History:
- San Marcos, CA (US) (2000)
- Carlsbad, CA (US) (2000 - 2003)
Company Filing History:
Years Active: 2000-2003
Title: Allister S Fraser: Innovator in Nucleoside Chemistry
Introduction
Allister S Fraser is a prominent inventor based in Carlsbad, CA (US). He has made significant contributions to the field of nucleoside chemistry, holding a total of 6 patents. His work focuses on the synthesis of modified nucleosides, which are crucial for various applications in biochemistry and molecular biology.
Latest Patents
Fraser's latest patents include innovative methods for the regioselective synthesis of 2′-O-modified nucleosides. These methods involve regioselective alkylation at the 2′-hydroxy position over the 3′-hydroxy position of nucleosides and nucleoside analogs. This process results in the formation of 2′-O-ester modified compounds. The subsequent reduction and derivatization of the 2′-O-ester yield 2′-O-modified nucleosides and nucleoside analogs. These compounds are particularly useful for synthesizing oligomeric compounds that exhibit improved hybridization affinity and nuclease resistance.
Career Highlights
Fraser has had a distinguished career, working at Isis Pharmaceuticals, Inc. His research has significantly advanced the understanding and application of nucleoside modifications in therapeutic contexts. His innovative approaches have paved the way for new methodologies in the synthesis of biologically relevant compounds.
Collaborations
Throughout his career, Fraser has collaborated with notable colleagues, including Muthiah Manoharan and Andrew Mamoru Kawasaki. These collaborations have further enhanced the impact of his research in the scientific community.
Conclusion
Allister S Fraser's contributions to nucleoside chemistry through his patents and collaborative efforts have established him as a key figure in the field. His work continues to influence the development of new therapeutic strategies and compounds.