Company Filing History:
1 out of 832,718 Years Active: 1991
Title: Alistair J Douglas: Innovator in Gastrin Antagonists
Introduction
Alistair J Douglas is a notable inventor based in La Jolla, CA (US). He has made significant contributions to the field of biochemistry, particularly in the development of gastrin antagonists. His innovative work has led to advancements in understanding the structural activity of gastrin molecules.
Latest Patents
Douglas holds a patent for "Novel C-terminal gastrin antagonists." This patent involves a series of derivatives of the biologically active C-terminus of gastrin, synthesized to study the molecule's structural activity. The research aimed to determine both the smallest and highest affinity inhibitors of gastrin.
Career Highlights
In his research, Douglas utilized five dogs with chronic gastric fistulae and Heidenhein pouches. After an 18-hour fast, he collected gastric juice from both the gastric fistula and pouch over 200 minutes at 10-minute intervals. The study monitored the Migrating Motor Complex (MMC) using a small balloon in the gastric antrum. The results indicated that all four peptides inhibited stimulated acid secretion, bringing it closer to control levels.
Collaborations
Douglas has collaborated with notable coworkers Richard F Murphy and Brian B Walker. Their combined expertise has contributed to the success of his research endeavors.
Conclusion
Alistair J Douglas's work in gastrin antagonists showcases his innovative spirit and dedication to advancing biochemistry. His contributions have the potential to impact medical science significantly.
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