Company Filing History:
Years Active: 1992
Title: Innovations of Ali Naqui
Introduction
Ali Naqui is an accomplished inventor based in Sparks, MD (US). He has made significant contributions to the field of immunoassays, with a focus on innovative methods for disease diagnosis. With a total of 2 patents, Naqui's work has the potential to impact medical diagnostics significantly.
Latest Patents
One of Naqui's latest patents is a "Method for immunoassay using lactoperoxidase, starch and iodine." This method involves a membrane coated with a capture antibody and starch. A solution suspected of containing an antigen is passed through the membrane, allowing the antigen to bind to the capture antibody. A conjugate of a detection antibody and lactoperoxidase is then passed through the membrane to form a sandwich on the membrane. A substrate composition including peroxide and iodide is introduced, where the lactoperoxidase catalyzes the oxidation of iodide by the peroxide to produce iodine, which reacts with the starch to yield a blue color. This invention also includes a kit of materials for performing the assay.
Another significant patent by Naqui is an "Assay for Lyme disease." This invention focuses on the diagnosis of Lyme disease through an immunoassay for anti-Borrelia burgdorferi antibodies in a patient's serum. The process includes the adsorption of cross-reactive antibodies in the serum with antigens of Acinetobacter calcoaceticus or Treponema phagedensis before binding the anti-Borrelia antibodies to Borrelia burgdorferi antigen absorbed onto a solid support. The preferred method is a flow-through assay using a porous membrane as the support, along with a dye-loaded liposome conjugated to a goat antihuman antibody for detection. This invention also includes a kit of materials for performing the assay.
Career Highlights
Ali Naqui is currently employed at Becton Dickinson and Company Limited, where he continues to innovate in the field of medical diagnostics. His work has been instrumental in developing new methods that enhance the accuracy and efficiency of disease detection.
Collaborations
Naqui has collaborated with notable coworkers, including Liane F Gossett and James P Mapes. Their combined expertise contributes to the advancement of innovative solutions in the medical field.
Conclusion
Ali Naqui's contributions to immunoassay technology demonstrate his commitment to