Company Filing History:
Years Active: 1996-1997
Title: Inventor Alexei Belenky: Pioneering Methods in Oligonucleotide Detection and Sequencing
Introduction
Alexei Belenky is a notable inventor based in Newton, Massachusetts, with a focus on groundbreaking techniques in the field of molecular biology. With two patents to his name, he has contributed significantly to advancing the methods used for detecting and sequencing oligonucleotides, which are crucial for biological research and medical diagnostics.
Latest Patents
Belenky's latest patents include a method of detecting sub-ppb levels of oligonucleotides in biological fluids and a method for sequencing short oligonucleotides.
The first patent details a method that enables the detection of a single-stranded target oligonucleotide within a biological fluid sample. By contacting the sample with specific helper and primer oligonucleotides, a labelled, double-stranded molecule is formed if a complementary oligonucleotide is present. The ligation of the primer and helper oligonucleotides serves as an indicator of the target oligonucleotide's presence.
The second patent offers a method for determining the nucleotide sequence of a target oligonucleotide. This technique involves creating a single-stranded ligation product containing both a target oligonucleotide and an auxiliary oligonucleotide. By employing a primer that is complementary to part of the auxiliary oligonucleotide, labeled and extended in the presence of specific nucleoside triphosphates, Belenky allows for the separation of extension products based on their lengths. The mobility of these products during separation ultimately leads to the determination of the oligonucleotide's sequence.
Career Highlights
Alexei Belenky works at Hybridon, Inc., a company dedicated to innovative molecular biology technologies. His career showcases a commitment to improving the detection and sequencing capabilities that scientists rely on in various research and clinical settings.
Collaborations
Throughout his career, Belenky has collaborated with esteemed colleagues including Aharon S. Cohen and Christopher M. Ott. These partnerships have fostered an environment of creativity and shared knowledge, driving advancements in their respective fields.
Conclusion
With his innovative methods and dedication to scientific progress, Alexei Belenky stands out as a prominent inventor in the molecular biology realm. His patents not only enhance the ability to detect and sequence oligonucleotides but also contribute to a greater understanding of biological processes, paving the way for future discoveries in research and medicine.