Alexandra Briner Crawley

Title: The Innovative Contributions of Alexandra Briner Crawley

Introduction

Alexandra Briner Crawley is a prominent inventor based in Cary, NC (US). She has made significant contributions to the field of biotechnology, particularly in the development of RNA-guided nucleases and DNA modifying enzymes. With a total of 16 patents to her name, Crawley is recognized for her innovative approaches to genetic editing and modification.

Latest Patents

Crawley's latest patents include groundbreaking work on RNA-guided nucleases and active fragments and variants thereof. These inventions provide compositions and methods for binding to a target sequence of interest, which can be utilized for cleaving or modifying that sequence. The compositions consist of RNA-guided nuclease (RGN) polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding these components. Additionally, she has developed systems for binding target sequences that incorporate RGN polypeptides and guide RNAs. Another significant patent involves novel deaminase polypeptides for targeted editing of nucleic acids, which includes fusion proteins that combine DNA-binding polypeptides with deaminases.

Career Highlights

Throughout her career, Crawley has worked with notable organizations such as Lifeedit Therapeutics, Inc. and North Carolina State University. Her work has been instrumental in advancing the field of genetic engineering, particularly in the application of CRISPR technology.

Collaborations

Crawley has collaborated with esteemed colleagues, including Tedd D Elich and Tyson D Bowen, contributing to her innovative research and development efforts.

Conclusion

Alexandra Briner Crawley stands out as a leading inventor in the biotechnology sector, with her patents paving the way for advancements in genetic editing technologies. Her contributions continue to influence the field and inspire future innovations.