Alexandr Jegorov

Title: Alexandr Jegorov: Innovator in Pharmaceutical Processes

Introduction

Alexandr Jegorov is a notable inventor based in Ceske Budejovice, Czech Republic. He has made significant contributions to the field of pharmaceuticals, particularly in the synthesis of analgesics. With a total of 2 patents, his work has garnered attention for its innovative approaches to drug development.

Latest Patents

Jegorov's latest patents include a process for the preparation of 3,14.beta.-dihydroxy-17-normorphinan. This process is crucial as it serves as a key intermediate in the semisynthetic synthesis of Butorphanol, an effective analgesic derived from thebaine. The synthesis involves a two-step N-demethylation and concerted dephenoxylation of 4-phenoxy-14.beta.-hydroxy-3-methoxymorphinan. The first step utilizes a chloroformate, while the second step employs sodium action in liquid ammonia, followed by O-demethylation using a complex of aluminium chloride and dialkylsulfide. Another significant patent focuses on the improvement of regeneration of injured striated muscles, utilizing n-butylamine in various forms as an effective treatment.

Career Highlights

Throughout his career, Jegorov has worked with prominent organizations such as Galena AS and the Czech Academy of Sciences. His experience in these institutions has allowed him to refine his skills and contribute to groundbreaking research in the pharmaceutical field.

Collaborations

Jegorov has collaborated with notable colleagues, including Roman Sobotik and Petr Bulej. These partnerships have facilitated the exchange of ideas and fostered innovation in their respective projects.

Conclusion

Alexandr Jegorov's contributions to pharmaceutical processes highlight his role as an innovator in the field. His patents reflect a commitment to advancing medical science and improving treatment options for patients.