This inventor holds 2 USPTO granted patents. Top assignees: Cornell University, Columbia University. Active years: 1998-1999.
Company Filing History:
2 out of 2,949 
1 out of 2,552 
Years Active: 1998-1999
Title: The Innovations of Alexander W. Langston
Introduction
Alexander W. Langston is a notable inventor based in New York, NY (US). He has made significant contributions to the field of gene expression regulation through his innovative research. With a total of 2 patents, Langston's work has implications for both normal and cancer cell differentiation.
Latest Patents
Langston's latest patents focus on regulating gene expression using retinoids with a CH.sub.2 OH group or related compounds. For the first time, certain retinoids with a side chain terminal CH.sub.2 OH group or ester or ether thereof, or aldehyde rather than a side chain terminal COOH group, have been indicated to bind to nuclear receptors. These compounds are biologically active in inducing cell differentiation of both normal and tumor cells. They activate gene expression through binding to nuclear receptor proteins. The compounds induce differentiation in normal and cancer cells, proving useful for treating leukemias, lymphomas, squamous cell carcinomas, deep (cystic) acne, psoriasis, and photodamaged or aging skin. Additionally, these compounds exhibit stability and in vitro half-life advantages over all-trans-retinoic acid and activity advantages over 13-cis retinoic acid.
Career Highlights
Langston has worked with prestigious institutions such as Cornell University and Columbia University. His research has contributed to advancements in the understanding of gene expression and its applications in medicine.
Collaborations
Some of his notable coworkers include Charles Achkar and Jochen Buck. Their collaborative efforts have furthered the impact of Langston's research in the scientific community.
Conclusion
Alexander W. Langston's innovative work in gene expression regulation has paved the way for new treatments in oncology and dermatology. His contributions continue to influence the field and inspire future research.