Company Filing History:
Years Active: 2015-2019
Title: Innovations by Alexander Lagadinos in Cytomegalovirus Research
Introduction
Alexander Lagadinos is an accomplished inventor based in Worcester, MA (US). He has made significant contributions to the field of virology, particularly in understanding and modulating human cytomegalovirus (HCMV) replication. With a total of 3 patents, his work has the potential to impact therapeutic strategies against HCMV infections.
Latest Patents
Lagadinos' latest patents focus on the modulation of HCMV replication through specific micro-RNAs. His inventions detail the roles of micro-RNA 132 (miR132), micro-RNA 145 (miR145), and micro-RNA 212 (miR212) in regulating gene expression during HCMV infection. Notably, miR145 is downregulated in infected cells, which affects the expression of target genes such as IRS-1. By transfecting cells with miR145 agents, such as mimetics, HCMV replication and protein expression can be reduced. Conversely, miR132 and miR212 are upregulated in infected cells, influencing the expression of genes like MeCP2 and RICS. The patents provide methods for attenuating HCMV replication by modulating these micro-RNAs and offer diagnostic methods and kits for detecting HCMV infections.
Career Highlights
Lagadinos is affiliated with the University of Massachusetts, where he conducts his research. His work has garnered attention for its innovative approach to tackling viral infections, particularly through the lens of micro-RNA modulation.
Collaborations
He collaborates with notable colleagues, including Timothy F Kowalik and Mariluz Rodriguez-Gonzalez, who contribute to the research efforts in the field of virology.
Conclusion
Alexander Lagadinos is a prominent inventor whose work on micro-RNAs and HCMV has the potential to lead to significant advancements in viral therapeutics. His contributions are paving the way for new methods to combat HCMV infections effectively.