This inventor holds 5 USPTO granted patents and 2 published patent applications, plus 1 CIPO patent and 2 EPO patents. Top assignees: Meiragtx UK Ii Limited, Meiragtx Gene Regulation Limited. Active years: 2019-2025.
Company Filing History:
Years Active: 2019-2025
Title: Alex R Boyne: Innovator in Gene Regulation
Introduction
Alex R Boyne is a prominent inventor based in Jersey City, NJ (US). He has made significant contributions to the field of gene regulation, holding a total of 5 patents. His work focuses on innovative methods for controlling gene expression through the use of aptamers and ribozymes.
Latest Patents
One of his latest patents is titled "Regulation of gene expression by aptamer-mediated modulation of alternative splicing." This invention provides a platform and methods for regulating the expression of a target gene using exposure to an aptamer ligand. The platform features a polynucleotide gene regulation cassette that is integrated into the target gene, including a synthetic riboswitch positioned within a 5' intron-alternative exon-3′ intron. The riboswitch consists of an effector region and a sensor region, allowing for the alternative exon to be spliced into the target gene mRNA when the ligand is absent, thus preventing expression. Conversely, when the ligand is present, the alternative exon is not spliced, enabling expression of the target gene.
Another notable patent is "Regulation of gene expression via aptamer-mediated control of self-cleaving ribozymes." This invention provides polynucleotide constructs for regulating gene expression through aptamer-based modulation of self-cleaving ribozymes. It includes methods for using these constructs to control gene expression in response to the presence or absence of a ligand that binds the aptamer. The invention also outlines methods for creating riboswitches that can either decrease or increase target gene expression based on the aptamer ligand.
Career Highlights
Throughout his career, Alex R Boyne has worked with several companies, including MeiraGTx UK II Limited and MeiraGTx Gene Regulation Limited. His innovative work in gene regulation has positioned him as a key figure in the biotechnology sector.
Collaborations
Alex has collaborated with notable professionals in his field, including Olivier F Danos and Michael J Volles. These collaborations have further enhanced his research and contributions to gene regulation technologies.
Conclusion
Alex R Boyne is a distinguished inventor whose work in gene regulation has led to significant advancements in biotechnology. His innovative patents and collaborations reflect his commitment to enhancing our understanding of gene expression.