Company Filing History:
3 out of 25 
1 out of 1 
1 out of 1 Years Active: 1984-1998
Title: The Innovative Contributions of Inventor Alberto Mangia
Introduction
Alberto Mangia, a distinguished inventor based in Milan, Italy, has made significant contributions to the field of pharmaceutical chemistry. With a total of five patents, his work particularly focuses on the synthesis of amikacin, a crucial antibiotic. Mangia's innovative processes enhance the efficiency and yield of this important drug.
Latest Patents
Mangia's most notable patents revolve around the synthesis of amikacin. The first patent outlines a process for synthesizing amikacin through the acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid. This method improves the industrial economy and synthesis yield by carefully selecting the reaction solvent and pH conditions.
His second patent describes a novel process for synthesizing amikacin starting from kanamycin A protected at specific positions. This method involves the reaction of kanamycin A with a bivalent metal cation in the presence of water, followed by the removal of the metal and purification of the raw product. The selectivity of acylation under these conditions is noted to be exceptionally high.
Career Highlights
Throughout his career, Alberto Mangia has worked with reputable companies, including Pierrel Spa and Gist Brocades Italy Spa. His experience in these organizations has contributed to his development as an innovator in the pharmaceutical sector. Mangia's patents not only represent personal achievements but also advance the industry’s capabilities in antibiotic synthesis.
Collaborations
Mangia has collaborated with notable coworkers, including Giorgio Ornato and Vincenzo Giobbio. These partnerships have enriched his research and broadened the potential applications of his innovations in the pharmaceutical field.
Conclusion
In summary, Alberto Mangia stands out as a prolific inventor whose innovative work has made significant strides in the synthesis of amikacin. His patents reflect not only his personal drive for excellence but also a broader commitment to advancing pharmaceutical science. Mangia's contributions will undoubtedly continue to impact the development of crucial medications in the future.