Company Filing History:
Years Active: 1998
Title: Alan Herbert: Innovator in Z-DNA Research
Introduction
Alan Herbert is a notable inventor based in Belmont, MA (US). He has made significant contributions to the field of molecular biology, particularly in the study of Z-DNA and its associated proteins. His work has implications for understanding gene regulation mechanisms.
Latest Patents
Alan Herbert holds a patent for a Z-DNA binding protein and its applications. The patent discloses the isolation of a 140,000 kDa protein that binds with high affinity to Z-DNA, a non-B-DNA conformer stabilized by negative supercoiling. This isolated protein also features a binding site for double-stranded RNA (dsRNA). The peptide sequences from this protein show similarity to double-stranded RNA adenosine deaminase (dsrad), an enzyme that deaminates adenosine in dsRNA to form inosine. Assays confirm that dsrad activity and Z-DNA binding are properties of the same molecule. This coupling of activities indicates a novel mechanism of gene regulation that is partially dependent on DNA topology.
Career Highlights
Alan Herbert is affiliated with the Massachusetts Institute of Technology, where he has conducted extensive research in molecular biology. His innovative work has led to advancements in understanding the interactions between DNA and RNA, contributing to the broader field of genetic research.
Collaborations
Alan Herbert has collaborated with notable scientists, including Alexander Rich, enhancing the depth and impact of his research.
Conclusion
Alan Herbert's contributions to the field of Z-DNA research and his innovative patent highlight his role as a significant inventor in molecular biology. His work continues to influence the understanding of gene regulation mechanisms.