Location History:
- Tucson, AZ (US) (1998 - 1999)
- Tampa, FL (US) (2016 - 2024)
Company Filing History:
18 out of 291 
2 out of 13 
2 out of 975 
Years Active: 1998-2025
Title: Innovations and Contributions of Alan F. List in the Field of Biomedical Research
Introduction
Alan F. List, based in Tampa, FL, is a prominent figure in the field of biomedical research. With a strong focus on innovative therapies, Dr. List has been credited with numerous contributions to the scientific community, particularly in the realm of patents. He holds an impressive portfolio of 19 patents, showcasing his commitment to advancing medical science.
Latest Patents
Among his latest patents is the development of stapled H2 pyrin peptides. These peptides are designed to function as inflammasome inhibitors, comprising an H2 helix of a pyrin domain, where at least two non-consecutive amino acids are covalently linked. The patent outlines methods for treating subjects with diseases by administering these peptides. Furthermore, it includes innovative techniques for inhibiting the binding between polypeptides that contain pyrin domains, thereby advancing therapeutic possibilities.
Another significant patent involves the TLR9 ligand trap. This innovation addresses the challenges posed by myelodysplastic syndrome (MDS) hematopoietic stem and progenitor cells, which translocate endosomal Toll-Like receptor (TLR)-9 to the plasma membrane. The designed chimeric protein fuses external epitopes of TLR9 to the Fc domain of human IgG4, creating a decoy receptor that recognizes harmful extracellular RNA:DNA hybrids and oxidized mitochondrial DNA. This invention seeks to neutralize danger-associated molecular patterns and mitigate the chronic inflammation contributing to MDS pathogenesis.
Career Highlights
Throughout his career, Alan F. List has held significant roles at reputable institutions, including the H. Lee Moffitt Cancer Center and Research Institute, Inc. His efforts have led to groundbreaking advancements in cancer research and treatment methodologies, solidifying his reputation as an influential figure in the biomedical field.
Collaborations
Dr. List has collaborated with notable colleagues such as Sheng Wei and David A. Sallman, contributing to various research projects that aim to enhance the understanding and treatment of hematological conditions. These partnerships reflect his commitment to fostering collective efforts in scientific inquiry.
Conclusion
Alan F. List's innovative contributions and extensive portfolio of patents play a crucial role in advancing biomedical research and understanding complex diseases. His ability to collaborate with other experts further enhances the impact of his work, solidifying his position as a key inventor in the medical field. As Dr. List continues to push the boundaries of science, his inventions promise to shape the future of therapeutic applications.