Alan Chang

Title: Alan Chang: Innovator in SARS-CoV-2 Research

Introduction

Alan Chang is a notable inventor based in Severn, MD (US). He has made significant contributions to the field of biotechnology, particularly in the development of methods related to the SARS-CoV-2 virus. His innovative work focuses on the efficient expression and purification of the receptor binding domain (RBD) of the virus, which is crucial for vaccine development.

Latest Patents

Alan Chang holds a patent for an "Efficient expression system of SARS-CoV-2 receptor binding domain (RBD), methods for purification and use thereof." This invention pertains to the production of the RBD of the Spike glycoprotein 1 of SARS-CoV-2 in mammalian cell expression systems. The patent outlines a method for producing a recombinant plasmid containing the coding sequence of the RBD, which is transfected into mammalian cells, such as Expi293. The process results in a high level of protein secretion, which is then purified using an N-terminal tag that can be removed by a specific protease. This invention also includes a recombinant expression vector carrying the RBD gene and methods for establishing a stable cell line for RBD production. The recombinant protein has potential applications in formulating pharmaceutical compositions, including vaccines for preventing SARS-CoV-2 induced diseases. Alan Chang has 1 patent to his name.

Career Highlights

Alan Chang is associated with Betagen Scientific Limited, where he applies his expertise in biotechnology to advance research and development efforts. His work is pivotal in addressing the challenges posed by the SARS-CoV-2 pandemic.

Collaborations

Alan collaborates with esteemed colleagues, including Fabrizio Maria Anella and Clement M Lee, to further enhance the impact of his research in the field.

Conclusion

Alan Chang's innovative contributions to the biotechnology sector, particularly in the context of SARS-CoV-2, highlight his role as a key inventor in the ongoing fight against viral diseases. His work not only advances scientific knowledge but also has the potential to lead to significant public health solutions.