Location History:
- Tokyo, JP (1998)
- Fussa, JP (1996 - 2001)
Company Filing History:
2 out of 27 
1 out of 1 Years Active: 1996-2001
Title: Akio Hamai: Pioneer in Chondroitinase Research
Introduction: Akio Hamai, an innovative inventor based in Fussa, Japan, has made significant contributions to the field of biochemistry through his research and patent developments. With a total of three patents to his name, Hamai has focused primarily on chondroitinase, a critical enzyme in the medical and pharmaceutical industries.
Latest Patents: Among his latest patents is a crystallizable, purified chondroitinase ABC, which has a molecular weight of approximately 100,000 daltons as measured by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and gel permeation chromatography. This enzyme features alanine as its N-terminal amino acid and proline as its C-terminal amino acid. His patent also details a process for purifying chondroitinase ABC by removing nucleic acids from an extract derived from chondroitinase ABC-producing microorganisms using chromatographic techniques, specifically employing weak or strong cation exchange resins. Additionally, he has developed a composition comprising chondroitinase along with serum albumin, gelatin, or a nonionic surfactant, which enhances the applicability of chondroitinase in various formulations.
Career Highlights: Akio Hamai has had an illustrious career, particularly known for his work with Seikagaku Kogyo Kabushiki Kaisha, commonly referred to as Seikagaku Corporation. His research in chondroitinase has positioned him as a notable figure within the biotechnology industry, contributing to advancements in therapeutic applications.
Collaborations: Throughout his career, Hamai has collaborated with esteemed colleagues, including Nobukazu Hashimoto and Hideo Mochizuki. These partnerships have facilitated the exchange of ideas and accelerated the development of innovative solutions in the field.
Conclusion: With three patents focusing on the purification and application of chondroitinase, Akio Hamai exemplifies the spirit of innovation in scientific research. His dedication to developing new processes and compositions has the potential to significantly impact pharmaceuticals and biochemistry, paving the way for future advancements in enzyme applications.