Agnes Marchio

Title: The Innovative Contributions of Agnes Marchio

Introduction

Agnes Marchio is a prominent inventor based in Paris, France. She has made significant contributions to the field of biotechnology, particularly in the study of retinoic acid receptors. With a total of 7 patents to her name, her work has had a profound impact on medical research and therapeutic applications.

Latest Patents

One of her latest patents involves the identification of a synthetic ligand for retinoic acid receptor beta. This method includes providing a sample with a synthetic compound, exposing it to cultured cells containing RARβ, and determining if the transcriptional expression of a gene encoding RARβ is upregulated compared to a control gene. A sample that upregulates the expression of RARβ is chosen as a synthetic ligand for RARβ. Another significant patent addresses a steroid/thyroid hormone receptor-related gene that is inappropriately expressed in human hepatocellular carcinoma. This research utilized a previously isolated hepatitis B virus integration to clone complementary DNA from a human liver cDNA library, revealing important insights into the structure and expression of the hap gene.

Career Highlights

Agnes has worked with prestigious institutions, including the Institut Pasteur, where she has contributed to groundbreaking research. Her innovative approaches have led to advancements in understanding the mechanisms of various diseases, particularly those related to liver cancer.

Collaborations

Throughout her career, Agnes has collaborated with notable scientists such as Pierre Tiollais and Anne Dejean. These partnerships have fostered a rich exchange of ideas and have propelled her research forward.

Conclusion

Agnes Marchio's contributions to the field of biotechnology and her innovative patents highlight her role as a leading inventor. Her work continues to influence research and development in medical science, paving the way for future discoveries.