Adrian Horgan

Title: Innovations of Adrian Horgan in Oligonucleotide Synthesis

Introduction

Adrian Horgan is a notable inventor based in Le Kremlin-Bicêtre, France. He has made significant contributions to the field of oligonucleotide synthesis, holding three patents that showcase his innovative methods and techniques.

Latest Patents

One of his latest patents is titled "One pot synthesis of sets of oligonucleotides." This invention focuses on methods for synthesizing multiple oligonucleotides within the same reaction vessel. The process involves providing various initiators attached to supports, each with a unique terminal nucleotide and 3-O-blocking group. The synthesis is achieved through repeated cycles of template-free enzymatic additions of 3'-O-blocked nucleoside triphosphates, which can be deblocked under specific conditions. The oligonucleotides are then released from the polynucleotides and supports.

Another significant patent is "Massively parallel enzymatic synthesis of nucleic acid strands." This invention outlines methods for the template-free enzymatic synthesis of different polynucleotides with predetermined sequences. It utilizes large-scale arrays of reaction sites, each linked to a working electrode for controlling deprotection and deblocking steps. Additionally, the invention incorporates proofreading techniques, allowing for sequencing of completed polynucleotides at specific reaction sites.

Career Highlights

Adrian Horgan is currently associated with Dna Script, a company that focuses on innovative solutions in the field of DNA synthesis. His work has contributed to advancements in oligonucleotide-based assays and synthesis techniques, enhancing the efficiency and effectiveness of nucleic acid production.

Collaborations

Adrian collaborates with notable colleagues such as Xavier Godron and Thomas Ybert, who contribute to the innovative environment at Dna Script. Their combined expertise fosters a culture of creativity and advancement in the field of biotechnology.

Conclusion

Adrian Horgan's contributions to oligonucleotide synthesis through his patents reflect his innovative spirit and dedication to advancing biotechnology. His work continues to influence the field, paving the way for new methodologies and applications in nucleic acid synthesis.