Adolf Mistr

Title: Adolf Mistr: Innovator in Platinum Complexes

Introduction

Adolf Mistr is a notable inventor based in Tisnov, Czech Republic. He has made significant contributions to the field of chemistry, particularly in the development of platinum complexes with therapeutic applications.

Latest Patents

Adolf Mistr holds 2 patents. His latest patents include a platinum complex and its preparation and therapeutic application. The disclosed platinum complex features a formula where X represents a halogen atom, and A represents a group —NH—R. The R group is a tricyclic hydrocarbon moiety containing 10 to 14 carbon atoms, which may be optionally substituted on the tricyclic ring by one or two alkyl groups, each containing 1 to 4 carbon atoms. Additionally, the complex can form an inclusion complex with beta- or gamma-cyclodextrin, which may also be substituted by hydroxyalkyl groups. The preparation process involves oxidation of a divalent platinum complex with hydrogen peroxide and optional substitution of hydroxyl groups with carboxylate groups using an acylating agent. These complexes are intended for use in the therapy of oncologic diseases.

Career Highlights

Adolf Mistr is associated with Pliva-Lachema a.s., where he continues to innovate in the field of pharmaceutical chemistry. His work focuses on the synthesis and application of platinum complexes in medical therapies.

Collaborations

Some of his notable coworkers include Frantisek Zak and Anna Poulova, who contribute to the collaborative efforts in research and development within the company.

Conclusion

Adolf Mistr's work in developing platinum complexes showcases his commitment to advancing therapeutic options for oncologic diseases. His innovative approach and collaboration with colleagues highlight the importance of teamwork in scientific research.