Location History:
- Stanford, CA (US) (2017)
- Palo Alto, CA (US) (2017 - 2019)
Company Filing History:
Years Active: 2017-2019
Title: The Innovative Contributions of Adam Shuhendler
Introduction
Adam Shuhendler is a notable inventor based in Palo Alto, California. He has made significant contributions to the field of imaging and drug safety screening, holding a total of 4 patents. His work focuses on developing advanced technologies that enhance the understanding of biological processes and improve patient outcomes.
Latest Patents
One of Shuhendler's latest patents is titled "Probe for imaging PARP-1 activity." This invention provides embodiments of a small molecule tracer for positron emission tomography (PET) imaging of the enzyme activity of PARP-1, which is crucial for DNA-damage sensing and plays a significant role in radiation therapy and chemotherapy response mechanisms. The PARP-1 tracers are derivatives of nicotinamide adenine dinucleotide (NAD), the natural substrate for PARP-1. These derivatives include a linker moiety that can be attached to a label moiety, such as a PET detectable fluorine, to generate a 6N-(triazo-PEG2-F)-NAD. The attachment of a chelating agent allows for the formation of a chelator-metal ion complex, making it especially advantageous for use in PET and MRI scanning detection systems.
Another significant patent is "Discrete imaging of hepatic oxidative and nitrosative stress with two-channel nanoparticles for in vivo drug safety screening." This invention encompasses activatable nanoprobes useful for in vivo longitudinal imaging of drug hepatotoxicity, using oxidative and nitrosative stress as safety biomarkers. The engineered nanoparticles allow for real-time monitoring of hepatotoxicity resulting from drug challenges. They enable the early detection of drug-induced hepatotoxicity by imaging the dose-dependence of oxidative and nitrosative stress, which precedes histological changes.
Career Highlights
Adam Shuhendler is affiliated with Leland Stanford Junior University, where he continues to advance his research and innovations. His work has garnered attention for its potential impact on medical imaging and drug safety.
Collaborations
Shuhendler has collaborated with notable researchers, including Jianghong Rao and Kanyi Pu, enhancing the scope and impact of his inventions.
Conclusion
Adam Shuhendler's innovative contributions to imaging and drug safety screening demonstrate his commitment to advancing medical technology. His patents reflect a deep understanding of biological processes and a dedication to