Company Filing History:
Years Active: 2023-2024
Title: Innovations in Cancer Research by Adam Shlien
Introduction
Adam Shlien is a notable inventor based in Toronto, Canada. He has made significant contributions to the field of cancer research through his innovative patents. With a total of 2 patents, Shlien's work focuses on advancing the understanding and treatment of cancer.
Latest Patents
One of Adam Shlien's latest patents is titled "System and method for cancer-cell specific transcription identification." This invention relates to a method that includes receiving nucleic acid data from one or more samples. It involves determining the variant allele fraction (VAF) of markers in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) within the nucleic acid data. The method compares the VAF of RNA relative to DNA for each marker and outputs the comparison as a quantification of cancer-cell specific changes in transcriptional output, which can serve as a marker of prognosis or therapeutic response in cancer.
Another significant patent by Shlien is "Profiling and treatment of hypermutant cancer." This method comprises determining a relative proportion for each of 96 mutation types. These mutation types are defined by the possible sequence changes in the context of nucleotides surrounding the mutation. The method assigns the tumor to at least one of eight defined clusters based on the determined relative proportions, allowing for the determination of at least one tumor characteristic based on the cluster assignment.
Career Highlights
Adam Shlien is currently affiliated with The Hospital for Sick Children, where he applies his expertise in cancer research. His work has been instrumental in developing methods that enhance the understanding of tumor characteristics and their implications for treatment.
Collaborations
Shlien collaborates with notable colleagues, including Matthew Zatzman and Uri Tabori. Their combined efforts contribute to the advancement of cancer research and treatment methodologies.
Conclusion
Adam Shlien's innovative patents and contributions to cancer research highlight his commitment to improving patient outcomes. His work continues to pave the way for advancements in understanding and treating cancer effectively.