The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
Nov. 05, 2021
Applicant:
The Hospital for Sick Children, Toronto, CA;
Inventors:
Adam Shlien, Toronto, CA;
Matthew Zatzman, Toronto, CA;
Assignee:
THE HOSPITAL FOR SICK CHILDREN, Toronto, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G16B 20/20 (2019.01); G16B 20/10 (2019.01); G16B 40/20 (2019.01); G16H 10/40 (2018.01); G16H 50/70 (2018.01);
U.S. Cl.
CPC ...
G16B 20/20 (2019.02); G16B 20/10 (2019.02); G16B 40/20 (2019.02); G16H 10/40 (2018.01); G16H 50/70 (2018.01);
Abstract
The present invention relates a system and method for cancer-cell specific transcription identification. The method including: receiving nucleic acid data from one or more samples; determining variant allele fraction (VAF) of markers in ribonucleic acid (RNA) in the nucleic acid data and markers for deoxyribonucleic acid (DNA) in the nucleic acid data; comparing the VAF of the RNA relative to the DNA for each of the markers; and outputting the comparison as a quantification of cancer-cell specific changes in transcriptional output as a marker of prognosis or therapeutic response in cancer.