Adam Oberstein

Title: Adam Oberstein: Innovator in Cellular Biochemistry

Introduction

Adam Oberstein is a prominent inventor based in Princeton, NJ (US). He has made significant contributions to the field of cellular biochemistry, particularly through his research on sirtuins and their regulatory roles in metabolic processes. With a total of 2 patents, Oberstein's work has implications for understanding cellular metabolism and potential therapeutic applications.

Latest Patents

Oberstein's latest patents focus on the lipoamidase activity of Sirtuin 4 (SIRT4) and its uses. One of the key applications provides a method for assaying pyruvate dehydrogenase complex (PDHC) activity in mammalian cells expressing human SIRT4. This method involves measuring the level of a dihydrolipoyllysine acetyltransferase (DLAT) lipoamide peptide with a specific amino acid sequence. His research demonstrates that SIRT4 acts as a cellular lipoamidase, negatively regulating PDHC activity through the hydrolysis of its lipoamide cofactors.

Career Highlights

Oberstein is affiliated with Princeton University, where he conducts his research and contributes to the academic community. His work has garnered attention for its innovative approach to understanding the biochemical pathways that govern cellular metabolism.

Collaborations

Throughout his career, Oberstein has collaborated with notable researchers, including Thomas E. Shenk and Todd M. Greco. These collaborations have enriched his research and expanded the impact of his findings in the scientific community.

Conclusion

Adam Oberstein's contributions to the field of cellular biochemistry through his patents and research at Princeton University highlight his role as an innovator. His work on SIRT4 and its regulatory mechanisms continues to advance our understanding of metabolic processes.