Adam Dengler

Title: Adam Dengler and Microfluidic Nucleic Acid Amplification

Introduction

Adam Dengler is an inventor associated with Redbud Labs, Inc. in Research Triangle Park, North Carolina. His work includes a patented approach to improving multiplexed, solid-phase isothermal nucleic acid amplification through microfluidic agitation. The available information identifies 1 patent associated with him.

Latest Patents

Dengler’s patent, “System and Methods of Using Microfluidic Agitation to Enhance Multiplexed Solid-Phase Isothermal Nucleic Acid Amplification,” describes a microfluidic device designed to improve fluid flow, mixing, and hybridization or capture efficiency in solid-phase assays.

The system uses a reaction chamber containing actuatable microposts. In some implementations, oligonucleotide primers are immobilized within the micropost field to capture and amplify target-specific nucleic acids from a sample. The invention also describes methods for producing micropost arrays on a substrate and printing capture spots, such as primer spots, onto the substrate surface.

Career Highlights

Dengler’s patent focuses on combining microfluidic agitation with solid-phase nucleic acid capture and amplification. By using actuatable microposts to promote mixing and molecular interactions, the approach aims to support multiplexed assays in which multiple targets can be analyzed.

Collaborations

Dengler is associated with Redbud Labs, Inc. His listed coworker is Katelyn Rose Kremer.

Conclusion

Adam Dengler’s patented work applies microfluidic micropost technology to enhance mixing and capture in multiplexed nucleic acid amplification, reflecting an engineering approach to improving solid-phase assay performance.