Location History:
- New York, NY (US) (1992 - 1994)
- San Diego, CA (US) (2014 - 2015)
- La Jolla, CA (US) (1999 - 2018)
Years Active: 1992-2018
Gerald M Edelman is a renowned inventor and researcher based in La Jolla, California, in the United States. With a total of 20 patents to his name, his contributions in the field of genetics and molecular biology are highly esteemed.
One of his latest patents is for "Chromosomal landing pads and related uses." This patent describes methods for the stable integration and expression of recombinant polynucleotides in host cells. The integration of these polynucleotides into the host genome occurs at specific chromosomal integration sites. These integration sites, found within or adjacent to specific genes in the CHO genome (such as Ank2, Cpsf4, C-Mos, and Nephrocystin-1/Mal), support robust transcription activities of foreign genes. Additionally, the patent also encompasses nucleic acid molecules and methods for inserting site-specific recombination sequences (chromosomal landing pads) into these specific chromosomal locations.
Another significant patent attributed to Gerald M Edelman is for "Translational enhancer-element dependent vector systems." This invention introduces a vector system designed to identify Translational Enhancer Elements (TEEs) and achieve gene overexpression through positive feedback. By leveraging both transcriptional and translational approaches, this system allows for precise control of gene expression levels. The patent also includes methods for screening libraries of random nucleotide sequences to identify translational elements and for the overproduction of proteins, applicable to research and industrial settings.
During his career, Gerald M Edelman has made significant contributions while working at esteemed institutions such as The Scripps Research Institute and the Neurosciences Research Foundation, Inc. He has collaborated with notable colleagues, including Vincent P Mauro and Wei Zhou.
Gerald M Edelman's innovative work and numerous patents have advanced our understanding of genetics and gene expression. His contributions continue to influence scientific research and have far-reaching implications in various industries.
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