The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Aug. 16, 2013
Applicant:
Academia Sinica, Taipei, TW;
Inventors:
Chi-Huey Wong, Rancho Santa Fe, CA (US);
Jim-Min Fang, Taipei, TW;
Yih-Shyun E. Cheng, Taipei, TW;
Charng-Sheng Tsai, New Taipei, TW;
Assignee:
Academia Sinica, Taipei, TW;
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/70 (2006.01); C12Q 1/40 (2006.01); C12N 9/96 (2006.01); C08B 37/00 (2006.01); C12Q 1/34 (2006.01); C12Q 1/04 (2006.01); C07H 13/04 (2006.01); C07H 13/12 (2006.01); C07H 5/00 (2006.01); C12N 9/24 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/40 (2013.01); C07H 5/00 (2013.01); C07H 13/04 (2013.01); C07H 13/12 (2013.01); C12N 9/2402 (2013.01); C12Q 1/04 (2013.01); C12Q 1/34 (2013.01); C12Q 1/70 (2013.01); C12Y 302/01018 (2013.01); G01N 2333/11 (2013.01);
Abstract
Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions.