The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2018
Filed:
Sep. 26, 2007
Christian Buchholz, Frankfurt, DE;
Sabrina Funke, Darmstadt, DE;
Klaus Cichutek, Langen, DE;
Roberto Cattaneo, Rochester, MN (US);
Christian Buchholz, Frankfurt, DE;
Sabrina Funke, Darmstadt, DE;
Klaus Cichutek, Langen, DE;
Roberto Cattaneo, Rochester, MN (US);
Abstract
The invention relates to the pseudotyping of retroviral vectors with heterologous envelope proteins derived from the Paramyxoviridae family, genus, and various uses of the resulting vector particles. The present invention is based on the unexpected and surprising finding that the incorporation ofF and H proteins having truncated cytoplasmic tails into lentiviral vector particles, and the complex interaction of these two proteins during cellular fusion, allows for a superior and more effective transduction of cells. Moreover, these pseudotyped vector particles allow the targeted gene transfer into a given cell type of interest by modifying a mutated and truncated H protein with a single-chain antibody or ligand directed against a cell surface marker of the target cell.