The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2017
Filed:
Aug. 15, 2016
Ramot AT Tel-aviv University Ltd., Tel Aviv, IL;
Technion Research & Development Foundation Ltd., Haifa, IL;
Itai Benhar, Rehovot, IL;
Nir Osherov, Tel Aviv, IL;
Vladimir Dergachev, Netanya, IL;
Alex Martin Szpilman, Kiryat Tivion, IL;
RAMOT AT TEL-AVIV UNIVERSITY LTD., Tel Aviv, IL;
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD., Haifa, IL;
Abstract
Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, Calkyl or phenyl; Ris (CH)wherein m is between 0 and 4; Rand Rare each independently H or Calkyl, Ris H or OH, Ris selected from a group consisting of: amide and alkyl, and Ris a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].