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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9745560 B1

PDFFull Text
Date of Patent:
Aug. 29, 2017

Filed:

Mar. 15, 2013

Expression of enzymes in yeast for lignocellulose derived oligomer cbp

Applicant:

Lallemand Hungary Liquidity Management Llc, Budapest, HU;

Inventors:

John E. McBride, Lyme, NH (US);

Erin Wiswall, Danbury, NH (US);

Indraneel Shikhare, Houston, TX (US);

Haowen Xu, Yorktown Heights, NY (US);

Naomi Thorngren, Norwich, VT (US);

Heidi H. Hau, St. Paul, MN (US);

Emily Stonehouse, Lebanon, NH (US);

Assignee:

Lallemand Hungary Liquidity Management LLC, Budapest, HU;

Attorney:

Nutter McClennen & Fish LLP

Primary Examiner:

Tekchand Saidha

Int. Cl.
CPC ...
C12N 1/20 (2006.01); C12N 9/18 (2006.01); C12P 19/02 (2006.01); C12P 19/14 (2006.01); C12N 9/24 (2006.01); C12P 7/10 (2006.01); C12N 9/42 (2006.01); C12N 9/40 (2006.01); C12N 9/38 (2006.01); C12P 3/00 (2006.01); C12P 7/16 (2006.01); C12P 7/28 (2006.01); C12P 7/52 (2006.01); C12P 7/56 (2006.01);
U.S. Cl.
CPC ...
C12N 9/18 (2013.01); C12N 9/2402 (2013.01); C12N 9/248 (2013.01); C12N 9/2437 (2013.01); C12N 9/2445 (2013.01); C12N 9/2465 (2013.01); C12N 9/2471 (2013.01); C12N 9/2482 (2013.01); C12N 9/2491 (2013.01); C12N 9/2494 (2013.01); C12P 3/00 (2013.01); C12P 7/10 (2013.01); C12P 7/16 (2013.01); C12P 7/28 (2013.01); C12P 7/52 (2013.01); C12P 7/56 (2013.01); C12P 19/02 (2013.01); C12P 19/14 (2013.01); C12Y 301/01072 (2013.01); C12Y 301/01006 (2013.01); C12Y 302/01021 (2013.01); C12Y 302/01037 (2013.01); C12Y 302/01072 (2013.01); C12Y 302/01131 (2013.01); C12Y 302/01139 (2013.01); Y02E 50/16 (2013.01);
Abstract

The present invention provides a multi-component enzyme system that hydrolyzes hemicellulose oligomers from hardwood which can be expressed, for example, in yeast such as. In some embodiments, this invention provides for the engineering of a series of biocatalysts combining the expression and secretion of components of this enzymatic system with robust, rapid xylose utilization, and ethanol fermentation under industrially relevant process conditions for consolidated bioprocessing. In some embodiments, the invention utilizes co-cultures of strains that can achieve significantly improved performance due to the incorporation of additional enzymes in the fermentation system.

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