The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
May. 26, 2016
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Institut Jean Paoli & Irene Calmettes, Marseilles, FR;
Universite D'aix-marseille, Marseilles, FR;
Universite Claude Bernard—lyon 1, Villeurbanne, FR;
Centre Leon Berard, Lyons, FR;
Julien Faget, Lyons, FR;
Christophe Caux, Lyons, FR;
Christine Menetrier-Caux, Lyons, FR;
Jacques Nunes, Marseilles, FR;
Daniel Olive, Marseilles, FR;
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris, FR;
INSTITUT JEAN PAOLI & IRENE CALMETTES, Marseilles, FR;
UNIVERSITE D'AIX-MARSEILLE, Marseilles, FR;
Universite Claude Bernard—Lyon 1, Villeurbanne, FR;
Centre Leon Berard, Lyons, FR;
Abstract
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.