The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2017
Filed:
Sep. 26, 2011
Sofia A. Casares, Potomac, MD (US);
Teodor D. Brumeanu, Potomac, MD (US);
Thomas L. Richie, Glenelg, MD (US);
Sofia A. Casares, Potomac, MD (US);
Teodor D. Brumeanu, Potomac, MD (US);
Thomas L. Richie, Glenelg, MD (US);
The United States of America as Represented by the Secretary of the Navy, Washington, DC (US);
Abstract
Provided is a transgenic animal model for testing immunogenicity and protective efficacy of human vaccines and the method for generating such a multitransgenic animal. Also disclosed are methods for screening compositions for human vaccine development. More specifically, a mouse model capable of expressing human leukocyte antigen DR4, and human costimulatory molecules (CD80) upon infusion of human HLA-matched hematopoietic stem cells, which can develop into a functional human immune system is provided.