The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2016
Filed:
Jun. 26, 2013
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Assignee:
GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart, BE;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 47/48 (2006.01); A61K 39/385 (2006.01); A61K 31/716 (2006.01); A61P 37/02 (2006.01); C08B 37/00 (2006.01); C07K 14/195 (2006.01); A61K 9/00 (2006.01); A61K 9/02 (2006.01); A61K 9/107 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0002 (2013.01); A61K 31/716 (2013.01); A61K 47/4823 (2013.01); A61K 47/4833 (2013.01); A61K 47/48261 (2013.01); A61K 9/0019 (2013.01); A61K 9/02 (2013.01); A61K 9/107 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/6037 (2013.01);
Abstract
Glucans having exclusively or mainly β-1,3 linkages are used as immunogens. These comprise β-1,3-linked glucose residues. Optionally, they may include β-1,6-linked glucose residues, provided that the ratio of β-1,3-linked residues to β-1,6-linked residues is at least 8:1 and/or there are one or more sequences of at least five adjacent non-terminal residues linked to other residues only by β-1,3 linkages. The glucans will usually be used in conjugated form. A preferred glucan source is curdlan, which may be hydrolyzed to a suitable form prior to conjugation.