The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2016
Filed:
Jul. 16, 2004
Thorsten Zank, Mannheim, DE;
Jörg Bauer, Ludwigshafen, DE;
Petra Cirpus, Mannheim, DE;
Amine Abbadi, Ebergötzen, DE;
Ernst Heinz, Hamburg, DE;
Xiao Qiu, Saskatoon, CA;
Patricia Vrinten, Saskatoon, CA;
Petra Sperling, Hamburg, DE;
Frederic Domergue, Hamburg, DE;
Astrid Meyer, Hamburg, DE;
Jelena Kirsch, Hamburg, DE;
Thorsten Zank, Mannheim, DE;
Jörg Bauer, Ludwigshafen, DE;
Petra Cirpus, Mannheim, DE;
Amine Abbadi, Ebergötzen, DE;
Ernst Heinz, Hamburg, DE;
Xiao Qiu, Saskatoon, CA;
Patricia Vrinten, Saskatoon, CA;
Petra Sperling, Hamburg, DE;
Frederic Domergue, Hamburg, DE;
Astrid Meyer, Hamburg, DE;
Jelena Kirsch, Hamburg, DE;
BASF Plant Science GmbH, Ludwigshafen, DE;
Abstract
The invention relates to a method for the production of multiply-unsaturated fatty acids in an organism, into which nucleic acids have been introduced, which code for polypeptides with Δ-5 elongase activity. Said nucleic acid sequences, optionally with further nucleic acid sequences, coding for polypeptides for the biosynthesis of fatty acids and lipid metabolism, are advantageously expressed in the organism. Nucleic acid sequences coding for a Δ-6 desaturase, a Δ-5 desaturase, Δ-4 desaturase and/or Δ-6 elongase activity are particularly advantageous and, advantageously, said saturases and elongases are derived fromor. The invention further relates to a method for the production of oils and/or triacylglycerides with an increased content of long-chain, multiply-unsaturated fatty acids. A particular embodiment of the invention is a method for the production of unsaturated ω-3 fatty acids and a method for the production of triglycerides with an increased content of unsaturated fatty acids, in particular, of Δ-3 fatty acids with more than three double bonds. Also disclosed is the production of a transgenic organism, preferably a transgenic plant, or a transgenic microorganism with increased content of ω-3 fatty acids, oils or lipids with ω-3 double bonds as a result of the expression of the elongases and desaturases employed in the above method, preferably in combination with ω-3 desaturases, for example a ω-3 desaturase from fungi of the family Pythiaceae such as the genus, for example, the genus and species, or a ω-3 desaturase from algae such as the family Prasinophyceae, for example, the genusand, particularly, the genus and speciesor diatomaceæ such as the genusand, particularly, the genus and species. The invention also relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms containing the nucleic acid sequences and/or the nucleic acid constructs and transgenic organisms containing said nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced according to the above method and use thereof and, furthermore, unsaturated fatty acids and triglycerides with an increased content of unsaturated fatty acids and use thereof.