The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2015
Filed:
Mar. 02, 2011
Avidor Shulman, Rakefet, IL;
Ilya Ruderfer, Carmiel, IL;
Tehila Ben-moshe, Koranit, IL;
Talia Shekhter, Givataim, IL;
Yaniv Azulay, Akko, IL;
Yoseph Shaaltiel, Kibbutz HaSolelim, IL;
Tali Kizhner, Yishuv Atzmon-Segev, IL;
Avidor Shulman, Rakefet, IL;
Ilya Ruderfer, Carmiel, IL;
Tehila Ben-Moshe, Koranit, IL;
Talia Shekhter, Givataim, IL;
Yaniv Azulay, Akko, IL;
Yoseph Shaaltiel, Kibbutz HaSolelim, IL;
Tali Kizhner, Yishuv Atzmon-Segev, IL;
Protalix Ltd., Carmiel, IL;
Abstract
Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.