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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9127267 B1

PDFFull Text
Date of Patent:
Sep. 08, 2015

Filed:

Nov. 12, 2012

Leucine beta roll domains and uses thereof

Applicant:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Inventors:

Scott Banta, Fairfield, CT (US);

Mark A. Blenner, Clemson, SC (US);

Ian Wheeldon, Riverside, CA (US);

Kevin Dooley, New York, NY (US);

Assignee:

The Trustees of Columbia University in the City of New York, New York, NY (US);

Attorneys:

Wiggin and Dana LLP

Anthony P. Gangemi

Primary Examiner:

James H Alstrum Acevedo

Assistant Examiner:

Zachary J Miknis

Int. Cl.
CPC ...
A01N 25/00 (2006.01); A61K 47/00 (2006.01); A61K 38/00 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A61K 38/04 (2006.01); C12N 9/88 (2006.01); A61L 27/22 (2006.01); A61L 27/50 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61L 15/32 (2006.01); A61L 15/42 (2006.01); A61L 15/44 (2006.01); A61L 15/46 (2006.01); A61L 15/60 (2006.01);
U.S. Cl.
CPC ...
C12N 9/88 (2013.01); A61L 15/32 (2013.01); A61L 15/42 (2013.01); A61L 15/44 (2013.01); A61L 15/46 (2013.01); A61L 15/60 (2013.01); A61L 27/227 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); C12Y 406/01001 (2013.01); A61L 2400/06 (2013.01);
Abstract

In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of calcium, the peptide is intrinsically disordered. Upon addition of calcium, the peptide forms a corkscrew-like structure. In one embodiment, one face of the beta roll is mutated to comprise leucine residues. In some embodiments, a leucine zipper forming helical domain to the engineered beta roll forms hydrogels by physical cross-linking in calcium rich environments.

Find Patent Forward Citations

Banta, Scott. (2015). Leucine beta roll domains and uses thereof (U.S. Patent No. 9127267). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9127267

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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