The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
Sep. 05, 2013
Abbvie B.v., Hoofddorp, NL;
Abbvie, Inc., North Chicago, IL (US);
Pieter Smid, Hoofddorp, NL;
Wouter I. Iwema Bakker, Hoofddorp, NL;
Hein K. A. C. Coolen, Hoofddorp, NL;
Leonardus A. J. M. Sliedregt, Hoofddorp, NL;
Maria J. P. van Dongen, Hoofddorp, NL;
Jacobus A. J. den Hartog, Hoofddorp, NL;
Adrian Hobson, Worcester, MA (US);
AbbVie B.V., Hoofddorp, NL;
AbbVie Inc., North Chicago, IL (US);
Abstract
The present invention relates to a fused heterocyclic derivative of the formula (I) The variables R1-R4, z, A, Q, X and Y are as defined in the claims. The following heterocycles are exemplified sub-structures of formula (I): The compounds of formula (I) are modulators of the S1P receptor (Sphingosine-1-phosphate receptor), More specifically, they are agonists of S1P5. The compounds have therapeutic use in treatment of cognitive disorders, age-relate cognitive decline and dementia.