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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8980571 B1

PDFFull Text
Date of Patent:
Mar. 17, 2015

Filed:

Apr. 21, 2011

Method of identifying a candidate compound which may inhibit α9-nachr overexpression or estrogen receptor-dependent transcription in nicotine-derived-compound-induced breast cancer cells

Applicants:

Chia-hwa Lee, Taipei, TW;

Ya-chieh Chang, Taipei, TW;

Ching-shyang Chen, Taipei, TW;

Shih-hsin Tu, Taipei, TW;

Ying-jan Wang, Taipei, TW;

Li-ching Chen, Taipei, TW;

Yu-jia Chang, Taipei, TW;

Po-li Wei, Taipei, TW;

Hui-wen Chang, Taipei, TW;

Chien-hsi Chang, Taipei, TW;

Ching-shui Huang, Taipei, TW;

Chih-hsiung Wu, Taipei, TW;

Yuan-soon Ho, Taipei, TW;

Inventors:

Chia-Hwa Lee, Taipei, TW;

Ya-Chieh Chang, Taipei, TW;

Ching-Shyang Chen, Taipei, TW;

Shih-Hsin Tu, Taipei, TW;

Ying-Jan Wang, Taipei, TW;

Li-Ching Chen, Taipei, TW;

Yu-Jia Chang, Taipei, TW;

Po-Li Wei, Taipei, TW;

Hui-Wen Chang, Taipei, TW;

Chien-Hsi Chang, Taipei, TW;

Ching-Shui Huang, Taipei, TW;

Chih-Hsiung Wu, Taipei, TW;

Yuan-Soon Ho, Taipei, TW;

Assignee:

Taipei Medical University, Taipei, TW;

Attorneys:

WPAT, P.C.

Anthony King

Kay Yang

Primary Examiner:

Jim Ketter

Int. Cl.
CPC ...
C12Q 1/68 (2006.01); A61K 31/138 (2006.01); A61K 31/4196 (2006.01); G01N 33/574 (2006.01); G01N 33/74 (2006.01); G01N 33/94 (2006.01);
U.S. Cl.
CPC ...
A61K 31/138 (2013.01); A61K 31/4196 (2013.01); G01N 33/57415 (2013.01); G01N 33/743 (2013.01); G01N 33/944 (2013.01);
Abstract

The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or α9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that α9-nAChR has an activating protein 1 (AP1)-binding site, that the α9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the α9-nAChR promoter at the AP1-binding site, indicating that ER-induced α9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.

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