The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2015
Filed:
Mar. 29, 2013
Cubist Pharmaceuticals, Inc., Lexington, MA (US);
Yu Gui Gu, Acton, MA (US);
Yong He, Bedford, MA (US);
Ning Yin, Lexington, MA (US);
Dylan C. Alexander, Watertown, MA (US);
Jason B. Cross, Acton, MA (US);
Robert Busch, Wakefield, MA (US);
Roland E. Dolle, Hopkinton, MA (US);
Chester A. Metcalf, III, Needham, MA (US);
Cubist Pharmaceuticals, Inc., Lexington, MA (US);
Abstract
Aryl substituted diazabicyclooctanes (DBO) compounds that inhibit β-lactamases of class A, class C or class D and potentiate β-lactam antibiotics are disclosed. In particular, this disclosure provides DBO compounds that, when used in the disclosed Synergy MIC Assay with a β-lactam antibiotic at a fixed concentration have an MIC of 8 μg/mL or less against one or more isogenic β-lactamase expressing bacterial strains.