The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 27, 2015

Filed:

Sep. 01, 2010
Applicants:

Baptiste Boit, Bethune, FR;

Philippe Lefevre, Haverskerque, FR;

Jose Lis, La Gorgue, FR;

Inventors:

Baptiste Boit, Bethune, FR;

Philippe Lefevre, Haverskerque, FR;

Jose Lis, La Gorgue, FR;

Assignee:

Roquette Freres, Lestrem, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B32B 5/16 (2006.01); A61K 9/14 (2006.01); C07C 29/78 (2006.01); C07C 31/26 (2006.01); A61K 9/20 (2006.01); C07H 1/06 (2006.01);
U.S. Cl.
CPC ...
C07C 29/78 (2013.01); C07H 1/06 (2013.01); C07C 31/26 (2013.01); A61K 9/2018 (2013.01);
Abstract

Disclosed is a powder composition of mannitol crystals, produced by: (i) the crystallization of mannitol in a solvent; followed by (ii) a step of separating the crystals from the resulting crystal suspension; (iii) a step of drying the crystals; and (iv) a selection step, the composition having a particle size distribution, as determined by laser particle sizing, of 72 to 99.9 vol % of particles having a particle size greater than 75 μm, of 0.1 to 60 vol % of particles larger than 250 μm, and a mean diameter of between 100 and 300 μm. Also described is a method for producing such a composition by a step of crystallizing a mannitol syrup followed by drying the mannitol crystals, a step of selecting particles, and a step of collecting a fraction of the powder composition including 72 to 99.9% of particles having a particle size greater than 75 μm.


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