The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 23, 2014
Filed:
Mar. 18, 2011
Young Woo Park, Daejeon, KR;
Ki Won JO, Gyeonggi-do, KR;
Srok Ho Yoo, Daejeon, KR;
Jung Yu, Daejeon, KR;
Dong Jin Kim, Daejeon, KR;
Sun-ha Yoon, Daejeon, KR;
Eun Jung Song, Daejeon, KR;
Eun Kyung Lee, Gyeonggi-do, KR;
Jin MI OH, Gyeonggi-do, KR;
Kyu Won Cho, Seoul, KR;
MI LA Cho, Seoul, KR;
Ho Youn Kim, Seoul, KR;
MI Kyung Park, Gyeonggi-do, KR;
Hye Jwa OH, Seoul, KR;
Jin Sil Park, Seoul, KR;
Yun Ju Woo, Seoul, KR;
Jae Kyeong Byun, Chungcheongbuk-do, KR;
Jun Geol Ryu, Gangwon-do, KR;
Young Woo Park, Daejeon, KR;
Ki Won Jo, Gyeonggi-do, KR;
Srok Ho Yoo, Daejeon, KR;
Jung Yu, Daejeon, KR;
Dong Jin Kim, Daejeon, KR;
Sun-Ha Yoon, Daejeon, KR;
Eun Jung Song, Daejeon, KR;
Eun Kyung Lee, Gyeonggi-do, KR;
Jin Mi Oh, Gyeonggi-do, KR;
Kyu Won Cho, Seoul, KR;
Mi La Cho, Seoul, KR;
Ho Youn Kim, Seoul, KR;
Mi Kyung Park, Gyeonggi-do, KR;
Hye Jwa Oh, Seoul, KR;
Jin Sil Park, Seoul, KR;
Yun Ju Woo, Seoul, KR;
Jae Kyeong Byun, Chungcheongbuk-do, KR;
Jun Geol Ryu, Gangwon-do, KR;
Korea Research Institute of Bioscience and Biotechnology, Taejeon-Si, KR;
Industry-Academic Cooperation Foundation, The Catholic University of Korea, Seocho-Gu, KR;
Abstract
The present invention relates to TNFR2-TWEAKR fusion protein, more precisely to TNFR2-TWEAKR fusion protein acting as a double-antagonist to TNF-α and TWEAK, known as major causes of autoimmune arthritis which is one of autoimmune diseases. When the composition comprising TNFR2-TWEAKR fusion protein was treated to Th17 cells, the secretion of the inflammatory cytokine IL-17 was reduced but the secretion of the anti-inflammatory cytokine IL-10 generated in Treg cells was increased. Such effect of TNFR2-TWEAKR fusion protein was far greater than that of a single protein such as TNFR2-Fc or TWEAK-Fc. The TNFR2-TWEAKR fusion protein of the present invention has not only excellent treatment effect on arthritis in CIA mouse model not also excellent treatment effect on autoimmune rheumatoid arthritis by increasing the expression of Treg, the immune suppressive cells. Therefore, the TNFR2-TWEAKR fusion protein of the present invention can be effectively used as an active ingredient for the composition for the prevention and treatment of autoimmune disease.