The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2014
Filed:
Feb. 16, 2007
Michael J. Smith, Silver Spring, MD (US);
Alison D. O'brien, Bethesda, MD (US);
Louise D. Teel, Silver Spring, MD (US);
Angela R. Melton-celsa, Sterling, VA (US);
Michael J. Smith, Silver Spring, MD (US);
Alison D. O'Brien, Bethesda, MD (US);
Louise D. Teel, Silver Spring, MD (US);
Angela R. Melton-Celsa, Sterling, VA (US);
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Rockville, MD (US);
Abstract
A chimeric Shiga toxoid according to the invention contains an enzymatically-inactivated StxA subunit and a native StxB subunit. This hybrid Shiga toxoid induces the production of broadly cross-reactive species of antibodies against Shiga toxin following immunization. The StxA subunit is modified so that it is enzymatically inactive. The invention thus encompasses the Shiga toxoid or fragments thereof and the nucleic acid sequence of the Shiga toxoid or fragments thereof. The invention further encompasses the production of a Shiga toxoid, the production of antibodies using the Shiga toxoid and methods of productions, and an immunogenic composition containing the Shiga toxoid.