The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2014
Filed:
Jun. 22, 2012
Applicants:
Piotr Bobrowicz, Hanover, NH (US);
W. James Cook, Hanover, NH (US);
Warren Kett, West Lebanon, NH (US);
Inventors:
Piotr Bobrowicz, Hanover, NH (US);
W. James Cook, Hanover, NH (US);
Warren Kett, West Lebanon, NH (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 21/06 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); A01N 43/78 (2006.01); C07D 277/26 (2006.01);
U.S. Cl.
CPC ...
Abstract
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.