The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 22, 2014

Filed:

Mar. 20, 2008
Applicants:

Richard Henderson, Cambridge, GB;

Christopher Gordon Tate, Cambridge, GB;

Francesca Magnani, Cambridge, GB;

Maria Josefa Serrano-vega, Cambridge, GB;

Yoko Shibata, Cambridge, GB;

Antony Johannes Warne, Cambridge, GB;

Malcolm Peter Weir, London, GB;

Inventors:

Richard Henderson, Cambridge, GB;

Christopher Gordon Tate, Cambridge, GB;

Francesca Magnani, Cambridge, GB;

Maria Josefa Serrano-Vega, Cambridge, GB;

Yoko Shibata, Cambridge, GB;

Antony Johannes Warne, Cambridge, GB;

Malcolm Peter Weir, London, GB;

Assignee:

Heptares Therapeutics Limited, Hertfordshire, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); C12Q 1/00 (2006.01); C07K 14/705 (2006.01); C12N 15/10 (2006.01); C07K 14/72 (2006.01); G01N 33/566 (2006.01);
U.S. Cl.
CPC ...
C07K 14/723 (2013.01); G01N 2333/726 (2013.01); C12N 15/1034 (2013.01); G01N 33/566 (2013.01);
Abstract

The present invention relates in some aspects to mutant G protein coupled receptors (GPCRs) and methods for selecting those with increased stability. In certain aspects, the invention relates to the selection and preparation of mutant GPCRs which have increased stability under a particular condition compared to their respective parent proteins.


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