The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2013
Filed:
Sep. 05, 2012
Jiri Damborsky, Brno, CZ;
Zbynek Prokop, Brno, CZ;
Tana Koudelakova, Brno, CZ;
Veronika Stepankova, Slavkov u Brna, CZ;
Radka Chaloupkova, Brno, CZ;
Eva Chovancova, Tisnov, CZ;
Artur Wiktor Gora, Bielsko-Biala, PL;
Jan Brezovsky, Brno, CZ;
Jiri Damborsky, Brno, CZ;
Zbynek Prokop, Brno, CZ;
Tana Koudelakova, Brno, CZ;
Veronika Stepankova, Slavkov u Brna, CZ;
Radka Chaloupkova, Brno, CZ;
Eva Chovancova, Tisnov, CZ;
Artur Wiktor Gora, Bielsko-Biala, PL;
Jan Brezovsky, Brno, CZ;
Masarykova Univerzita, Brno, CZ;
Abstract
Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function.